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KMID : 0358320080490110974
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Korean Journal of Urology
2008 Volume.49 No. 11 p.974 ~ p.980
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Epidermal Growth Factor Receptor as Predicting Factor on Biochemical Recurrence after Radical Prostatectomy: A Prospective Study
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Lee Jeong-Woo
Jeong Jae-Young
Han Kyung-Seok
Seo Ho-Kyung
Chung Jin-soo
Lee Kang-Hyun
Park Weon-Seo
Cho Kang-Su
Kim Eun-Kyoung
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Abstract
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Purpose: We investigated epidermal growth factor receptor(EGFR) expression in prostate cancer(PCa) and their potential role as predicting factor on biochemical recurrence(BCR).
Materials and Methods: Between February 2005 and February 2007, EGFR expression were prospectively evaluated in a consecutive series of 88 PCa patients with the following characteristics: 66 patients treated with retropubic radical prostatectomy(RRP); 22 patients treated with neoadjuvant hormonal therapy followed by RRP. The relationship between EGFR expression and several clinicopathologic parameters were evaluated. The probability of BCR-free survival was determined using the Kaplan-Meier method.
Results: EGFR expression, was evaluated by immunohistochemistry, was found in 31 of 88(35.2%) patients. 8 of 31 EGFR-positive patients(25.8%) had BCR, whereas only 5 of 57 EGFR-negative patients(8.8%) had BCR (p=0.031) during a median follow-up of 21 months. Among several variables, high serum prostate-specific antigen values(≥20), extraprostatic extension, seminal vesicle invasion, and EGFR expression were the significant predictors of BCR on univariate analysis. But, multivariate analysis showed that no variable was significant predictor of BCR. EGFR-negative patients had a significantly longer mean BCR-free survival time than EGFR-positive patients(p=0.027).
Conclusions: EGFR expression could be an potential predicting factor on BCR following RRP.
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KEYWORD
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Epidermal growth factor receptor, Prostate cancer, Biochemical recurrence
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